Administration of Capsiate , a Non - Pungent Capsaicin Analog , Energy Metabolism and Suppresses Body Fat Accumulation inPromotesMice
نویسنده
چکیده
major pungent component in fruits of CZTpsium, has been reported to increase the catecholamine secretioni) and energy expenditure2) and suppress body fat accumulation by long-term treatment3} in experimental animal studies. Although hot peppers and capsaicin may be used in a diet therapy for obesity, their usage as a food additive or a drug is limited by its strong pungency and nociceptive activity for hu-
منابع مشابه
Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog.
Capsiate is a nonpungent capsaicin analog, a recently identified principle of the nonpungent red pepper cultivar CH-19 Sweet. In the present study, we report that 2-wk treatment of capsiate increased metabolic rate and promoted fat oxidation at rest, suggesting that capsiate may prevent obesity. To explain these effects, at least in part, we examined uncoupling proteins (UCPs) and thyroid hormo...
متن کاملThe effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans.
Consumption of spicy foods containing capsaicin, the major pungent principle in hot peppers, reportedly promotes negative energy balance. However, many individuals abstain from spicy foods due to the sensory burn and pain elicited by the capsaicin molecule. A potential alternative for nonusers of spicy foods who wish to exploit this energy balance property is consumption of nonpungent peppers r...
متن کاملIntragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses.
The sympathetic thermoregulatory system controls the magnitude of adaptive thermogenesis in correspondence with the environmental temperature or the state of energy intake and plays a key role in determining the resultant energy storage. However, the nature of the trigger initiating this reflex arc remains to be determined. Here, using capsiate, a digestion-vulnerable capsaicin analog, we exami...
متن کاملAssessment of the biological similarity of three capsaicin analogs (Capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits.
CH-19 Sweet is a newly found chili pepper breed bearing much less pungent fruits. Because CH-19 Sweet fruits were found to contain three analogs (capsinoids) of capsaicin, a major component of pungency of hot peppers (the analogs are capsiate or CST, dihydrocapsiate or DCT, and nordihydrocapsiate or NDCT), we assessed in this study the bio-potencies of these three capsinoids by comparing them w...
متن کاملCH-19 sweet, nonpungent cultivar of red pepper, increased body temperature in mice with vanilloid receptors stimulation by capsiate.
We investigated the effect of CH-19 Sweet, a nonpungent cultivar of red pepper, and capsiate, a nonpungent capsaicin analog found in CH-19 Sweet on body temperature in mice. The body temperature was recorded from conscious and unrestrained mice by use of a telemetry system. The body temperature in the mice administered CH-19 Sweet was higher than in the mice administered California-Wandar, whic...
متن کامل